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The AMP PD Knowledge Portal was developed to host and share resources related to Parkinson’s disease research and remains fully operational. We continue to maintain and accept Parkinson’s disease and related disorders data and resources throughout this review process.

αSyn‑SAA Summary

In collaboration with The Michael J. Fox Foundation, Amprion Alpha‑Synuclein Seed Amplification Assay (Amprion 𝞪S-SAA) results are now available in AMP PDRD, spanning 1,509 total participants from three Parkinson’s disease cohorts: the Parkinson’s Progression Markers Initiative (PPMI), The Fox Investigation for New Discovery of Biomarkers (BioFIND), and the LRRK2 Cohort Consortium (LCC). This release provides a large‑scale, cross‑cohort view of misfolded alpha‑synuclein pathology, a key biological hallmark of Parkinson’s disease, using a highly sensitive molecular assay. By integrating αSyn‑SAA results with the rich longitudinal clinical, genetic, and molecular multi‑omic data available in AMP PD, researchers can more precisely stratify participants, interrogate disease heterogeneity, and explore relationships between alpha‑synuclein pathology and disease progression. 

Available α Syn‑SAA Results with Corresponding Participant Data

The summary table below describes the availability of matched longitudinal participant‑level αSyn‑SAA, clinical, genomic, transcriptomic, and proteomic data by cohort.

 Visit Month
ProjectData TypeTotal Subjects
w/SAA		BL0.5369121824303642485460728496108
PPMI
Project
237		Clinical643                  
Genomics637                  
SAA64321005270396059019015032301
RNAseq5795460040104570413034500000000
Proteomics2982420419612185203315801752125474024
PPMI
Project
155		Clinical609                  
Genomics601                  
SAA60960900002030100010000
RNAseq5565220039004380396030200000000
Proteomics2262190217401933181214401591112403824
BioFind
Project
122		Clinical190                  
Genomics160                  
SAA190                  
RNAseq187                  
LCC
Project
536		Clinical67                  
Genomics67                  
SAA67                  

Methodology and Data Interpretations

Alpha‑synuclein seed amplification assay (αSyn‑SAA) methodologies continue to evolve, with differences in assay platforms, protocols, biospecimen types, and analytical thresholds across studies. As a result, αSyn‑SAA results available in AMP PDRD reflect project‑specific methods implemented within each contributing cohort, including PPMI, BioFIND, and LCC. Researchers are encouraged to reference the cohort‑level methodology documentation that is available in the AMP PDRD portal to fully understand assay characteristics, performance metrics, and data interpretive considerations.

Data Availability & Reference Workspace

Researchers can access the SAA data via the workspace here.